N-(4-Isoxazolylthiazol-2-yl) oxamic acid derivatives as potent orally active antianaphylactic agents

D Chiarino, G Grancini, V Frigeni, I Biasini…

Index: Chiarino; Grancini; Frigeni; Biasini; Carenzi Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 600 - 605

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Citation Number: 18

Abstract

A series of N-(4-isoxazolylthiazol-2-yl) oxamic acid derivatives was synthesized and tested on the passive cutaneous anaphylaxis (PCA) model in rats to verify its potential antianaphylactic activity. These compounds were prepared by reaction of an appropriate bromoacetylisoxazole with thiourea to give the corresponding aminothiazole and subsequent condensation with an oxalic acid monoester chloride to yield, following the ...