Laboratory-scale synthesis of nitriles by catalysed dehydration of amides and oximes under flash vacuum pyrolysis (FVP) conditions

JA Campbell, G McDougald, H McNab, LVC Rees…

Index: Campbell, Jacqueline A.; McDougald, Graham; McNab, Hamish; Rees, Lovat V. C.; Tyas, Richard G. Synthesis, 2007 , # 20 p. 3179 - 3184

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Citation Number: 15

Abstract

Abstract Dehydration of amides and oximes can be catalysed by 3 Å molecular sieves or by tungsten trioxide under flash vacuum pyrolysis (FVP) conditions. This provides a convenient synthesis of aliphatic, aromatic, and heterocyclic nitriles, generally in excellent yields under mild, neutral, and short contact time conditions.