Design, synthesis and anticancer activities of diaryl urea derivatives bearing N-acylhydrazone moiety

…, X Zhai, L Wang, J Yang, Z Tan, P Gong

Index: Zhang, Bei; Zhao, Yanfang; Zhai, Xin; Wang, Lihui; Yang, Jingyu; Tan, Zehui; Gong, Ping Chemical and Pharmaceutical Bulletin, 2012 , vol. 60, # 8 p. 1046 - 1054

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Citation Number: 15

Abstract

A new series of diaryl urea derivatives bearing N-acylhydrazone moiety were designed and synthesized. All the target compounds were evaluated for their cytotoxic activities in vitro against human lung adenocarcinoma epithelial cell line (A549), human breast cancer cell line (MDA-MB-231) and human leukemia cell line (HL-60) by standard 3-(4, 5- dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. Several compounds ( ...