Synthesis

Synthesis of (S, R, R, R)-α, α′-Iminobis (methylene) bis (6-fluoro-3H, 4H-dihydro-2H-1-benzopyran-2-methanol)

NX Wang, AG Yu, GX Wang, XH Zhang, QS Li, Z Li

Index: Wang, Nai-Xing; Yu, An-Guang; Wang, Gui-Xia; Zhang, Xiu-Hui; Li, Qian-Shu; Li, Zhen Synthesis, 2007 , # 8 p. 1154 - 1158

Full Text: HTML

Citation Number: 9

Abstract

Abstract The β 1-adrenergic antagonist (S, R, R, R)-α, α′-iminobis (methylene) bis (6-fluoro- 3H, 4H-dihydro-2H-1-benzopyran-2-methanol) was synthesized from natural chiral pool starting materials through an efficient, convergent synthetic strategy. The cyclization mechanism of the key step was investigated using computer modeling and is discussed.