Pyridazine-derived γ-secretase modulators

…, Y Jin, JN Xiang, E Yang, A Eatherton, B Smith…

Index: Wan, Zehong; Hall, Adrian; Jin, Yun; Xiang, Jia-Ning; Yang, Eric; Eatherton, Andrew; Smith, Beverley; Yang, Guang; Yu, Haihua; Wang, Ju; Ye, Liang; Lau, Lit-Fui; Yang, Ting; Mitchell, William; Cai, Wei; Zhang, Xiaomin; Sang, Yingxia; Wang, Yonghui; Tong, Zhaolong; Cheng, Ziqiang; Hussain, Ishrut; Elliott, John D.; Matsuoka, Yasuji Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 13 p. 4016 - 4019

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Citation Number: 18

Abstract

Abstract SAR of a novel series of pyridazine-derived γ-secretase modulators is described. Compound 25 was found to be a potent modulator in vitro, which on further profiling, was found to decrease Aβ42 and Aβ40, and maintain the levels of total Aβ. Furthermore, 25 demonstrated excellent pharmacokinetic parameters as well as good CNS penetration in the rat.