Identification of novel 7-amino-5-methyl-1, 6-naphthyridin-2 (1H)-one derivatives as potent PI3K/mTOR dual inhibitors

S Lin, F Han, P Liu, J Tao, X Zhong, X Liu, C Yi…

Index: Lin, Songwen; Han, Fangbin; Liu, Peng; Tao, Jing; Zhong, Xuechao; Liu, Xiujie; Yi, Chongqin; Xu, Heng Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 3 p. 790 - 793

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Citation Number: 4

Abstract

Abstract Inhibition of the phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway is one of the most intensively studied approaches to cancer therapy. Rational design led to the identification of novel 7-amino-5-methyl-1, 6- naphthyridin-2 (1H)-one derivatives as potent PI3K/mTOR dual inhibitors. Design, synthesis and structure activity relationship are reported.