Highly N2??Selective Palladium??Catalyzed Arylation of 1, 2, 3??Triazoles

S Ueda, M Su, SL Buchwald

Index: Ueda, Satoshi; Su, Mingjuan; Buchwald, Stephen L. Angewandte Chemie - International Edition, 2011 , vol. 50, # 38 p. 8944 - 8947

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Citation Number: 64

Abstract

N-Substituted 1, 2, 3-triazoles have found widespread applications in material science and medicinal chemistry.[1, 2] Because of the importance of this structural motif, many practical synthetic methods have been developed. Among them, the Huisgen azide–alkyne dipolar cycloaddition (AAC) is perhaps the most commonly utilized method for the synthesis of N1- substituted 1, 2, 3-triazoles.[3] In particular, recent developments in copper-[4] and ...