Evaluation of 4-hydroxy-6-methyl-3-pyridinecarboxylic acid and 2, 6-dimethyl-4-hydroxy-3-pyridinecarboxylic acid as chelating agents for iron and aluminium

…, MG Ferlin, P Brun, I Castagliuolo, RA Yokel…

Index: Dean, Annalisa; Ferlin, Maria Grazia; Brun, Paola; Castagliuolo, Ignazio; Yokel, Robert A.; Venzo, Alfonso; Giorgio Bombi; Di Marco, Valerio B. Inorganica Chimica Acta, 2011 , vol. 373, # 1 p. 179 - 186

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Citation Number: 8

Abstract

Abstract 4-Hydroxy-6-methyl-3-pyridinecarboxylic acid (DQ6) and the new compound 2, 6- dimethyl-4-hydroxy-3-pyridinecarboxylic acid (DQ726) were evaluated for possible application for iron (Fe) and aluminium (Al) chelation therapy. Metal/ligand solution chemistry, cytotoxicity, octanol/water partitioning (D o/w), and chelation efficiency were studied. The solution chemistry of the two ligands with Fe (III) and Al (III) was investigated ...