Tetrahedron letters

Synthesis of 6-, 7-, and 8-membered lactones via the nickel-catalysed electrochemical arylation of electron-deficient olefins

JC de Mendonça Cavalcanti, MOF Goulart, E Léonel…

Index: De Mendonca Cavalcanti, Janesmar Camilo; Fonseca Goulart, Marilia Oliveira; Leonel, Eric; Nedelec, Jean-Yves Tetrahedron Letters, 2002 , vol. 43, # 36 p. 6343 - 6345

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Citation Number: 8

Abstract

A nickel-catalysed electroreductive process of arylation of α, β-unsaturated carboxylic esters has been applied to the synthesis of medium-sized lactones. Of the two possible approaches investigated in this study, the most efficient one involves first the electrochemical condensation, followed by the lactonisation.