Three bacteriorhodopsins with ring??didemethylated 6??s??locked chromophores and their properties

M Groesbeek, AJJ Van Galen, JH Ippel…

Index: Groesbeek, M.; Galen, A. J. J. van; Ippel, J. H.; Berden, J. A.; Lugtenburg, J. Recueil des Travaux Chimiques des Pays-Bas, 1993 , vol. 112, # 4 p. 237 - 246

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Citation Number: 6

Abstract

Abstract Three novel, 6-s-locked rigidified retinals, racemic all-E 1, 5-didemethyl-8, 16- methanoretinal, all-E 1, 1-didemethyl-8, 18-methanoretinal and all-E 8a, 18-didehydro-1, 1- didemethyl-8, 18-methanoretinal were prepared in good yield in high purity on a 100-mg scale. For the preparation of the key intermediate in the synthesis of 1, 5-didemethyl-8, 16- methanoretinal, reductive cyanation of an unsaturated cyanohydrin to the corresponding ...