Synlett

Efficient and novel method for thiocyanation of aromatic and hetero-aromatic compounds using bromodimethylsulfonium bromide and ammonium thiocyanate

DS Bhalerao, KG Akamanchi

Index: Bhalerao, Dinesh S.; Akamanchi, Krishnacharya G. Synlett, 2007 , # 19 p. 2952 - 2956

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Citation Number: 25

Abstract

To begin our study, effect of various reaction parameters on the aromatic thiocyanation of o-cresol (1) was examined as shown in Table [1] . In the preliminary experiment, the reaction using BDMS was compared with that involving molecular bromine. Reaction was carried out on o-cresol (5 mmol) with bromine (7.5 mmol) or BDMS (7.5 mmol) and NH 4 SCN (15 mmol) in acetonitrile. When Br 2 was added to the suspension of NH 4 SCN in acetonitrile, an ...