Concise preparation of amino-5, 6, 7, 8-tetrahydroquinolines and amino-5, 6, 7, 8-tetrahydroisoquinolines via catalytic hydrogenation of acetamidoquinolines and …

KA Skupinska, EJ McEachern, RT Skerlj…

Index: Skupinska, Krystyna A.; McEachern, Ernest J.; Skerlj, Renato T.; Bridger, Gary J. Journal of Organic Chemistry, 2002 , vol. 67, # 22 p. 7890 - 7893

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Citation Number: 24

Abstract

A method to prepare amino-substituted 5, 6, 7, 8-tetrahydroquinolines and 5, 6, 7, 8- tetrahydroisoquinolines via catalytic hydrogenation of the corresponding acetamido- substituted quinolines and isoquinolines followed by acetamide hydrolysis is described. The yields of the products are good when the acetamido substituent is present on the pyridine ring and moderate with the acetamido substituent on the benzene ring. This method has ...