Synthesis of 4, 10??dihydro??4, 10??dioxo??1H [1] benzothiopyrano [3, 2??B] pyridine and 7??oxo??7, 13??dihydro [1] benzothiopyrano [2, 3??b]??1, 5??benzodiazepine

H Nakazumi, T Endo, T Nakaue…

Index: Nakazumi; Endo; Nakaue; Kitao Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 1 p. 89 - 92

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Citation Number: 11

Abstract

Abstract 3-Amino-4H-1-benzothiopyran-4-one (3-aminothiochromone) was easily prepared by reaction of 3-bromo-thiochromen-4-one with sodium azide in methanol-water. Condensation of 3-aminothiochromone with diethyl ethoxymethylenemalonate and with dimethyl acetylenedicarboxylate gave intermediates, which were thermally cyclized to give 4, 10-dihydro-4, 10-dioxo-1H [1] benzothiopyrano [3, 2-b] pyridinecarboxylates. 3-Formyl- ...