Bulletin of the Korean Chemical Society

Synthesis of new 6-(4-fluorophenyl)-5-(2-substituted pyrimidin-4-yl) imidazo [2, 1-b] thiazole derivatives and their antiproliferative activity against melanoma cell line

JH Park, CH Oh

Index: Park, Jin-Hun; Oh, Chang-Hyun Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 10 p. 2854 - 2860

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Citation Number: 17

Abstract

Abstract Synthesis of a new series of pyrimidinyl-imidazo [2, 1-b] thiazole derivatives is described. Their antiproliferative activity against A375 human melanoma cell line was tested and the effect of substituents on the pyrimidinyl ring side chain was investigated. The biological results indicated that most of the newly synthesized compounds showed moderate activity against A375, compared with Sorafenib. Among all of these derivatives, ...