Bioactivation of 6, 7-Dimethyl-2, 4-di-1-pyrrolidinyl-7 H-pyrrolo [2, 3-d] pyrimidine (U-89843) to Reactive Intermediates That Bind Covalently to Macromolecules and …

…, LS Banitt, TM Schwartz, DC Zimmermann…

Index: Zhao, Zhiyang; Koeplinger, Kenneth A.; Padbury, Guy E.; Hauer, Michael J.; Bundy, Gordon L.; Banitt, Lee S.; Schwartz, Theresa M.; Zimmermann, David C.; Harbach, Philip R.; Mayo, Judy K.; Aaron, C. Sidney Chemical Research in Toxicology, 1996 , vol. 9, # 8 p. 1230 - 1239

Full Text: HTML

Citation Number: 11

Abstract

U-89843 is a novel pyrrolo [2, 3-d] pyrimidine antioxidant with prophylactic activity in animal models of lung inflammation. During preclinical safety evaluation, U-89843 was found to give a positive response in the in vitro unscheduled DNA synthesis (UDS) assay, an assay which measures DNA repair following chemically-induced DNA damage in metabolically competent rat hepatocytes. Incubation of [14C] U-89843 with liver microsomes resulted in ...