Organic letters

Palladium-Catalyzed Decarboxylative Allylation and Benzylation of N-Alloc and N-Cbz Indoles

TD Montgomery, Y Zhu, N Kagawa, VH Rawal

Index: Montgomery, Thomas D.; Zhu, Ye; Kagawa, Natsuko; Rawal, Viresh H. Organic Letters, 2013 , vol. 15, # 5 p. 1140 - 1143

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Citation Number: 45

Abstract

A set of general methods for the palladium-catalyzed decarboxylative C3-allylation and C3- benzylation of indoles, starting from the corresponding N-alloc and N-Cbz indoles, respectively, is reported. This chemistry provides ready access to a wide range of functionalized indolenines in good to excellent yields. A tandem process, wherein the palladium catalyzed allylation chemistry is coupled with a Mizoroki–Heck reaction, offers a ...