Cell Stem Cell 2017-06-01

Gli-fully Halting the Progression of Fibrosis

Christian F. Guerrero-Juarez, Maksim V. Plikus

Index: 10.1016/j.stem.2017.05.003

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Abstract

Activating triggers, selective markers, and the residual regenerative potential of scar-forming myofibroblasts are largely determined by their origin. In this issue ofCell Stem Cell, Schneider et al. report that bone marrow myofibroblasts derive from Gli1+mesenchymal stromal cells and that a Gli inhibitor targets them for elimination in mice and humans, ameliorating fibrosis.