Cell Stem Cell 2017-07-06

Modeling the Glomerular Filtration Barrier: Are You Kidney-ing Me?

Paola Romagnani, Laura Lasagni

Index: 10.1016/j.stem.2017.06.008

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Abstract

Podocyte depletion drives kidney disease and kidney failure progression, but podocyte complexity at the glomerular filtration barrier is difficult to model in vitro. InNature Biomedical Engineering, Musah et al. (2017) developed a multifluidic device with iPS-derived podocytes mimicking a functional glomerular filtration barrier that elevates standards for modeling glomerular diseases.