Cancer Cell 2017-07-10

HDAC Inhibitors Finally Open Up: Chromatin Accessibility Signatures of CTCL

Christopher J. Ott, Catherine J. Wu

Index: 10.1016/j.ccell.2017.06.008

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Abstract

In this issue ofCancer Cell, Qu et al. describe the chromatin accessibility profiles of cutaneous T cell lymphoma, with dynamic assessments of response and resistance to histone deacetylase inhibitor therapy. Their “personal regulome” analysis framework reveals chromatin features that may be predictive of clinical response to epigenetic therapy.