Chemical and pharmaceutical bulletin

Reactivities of 6-Amino-1, 3-dimethyl-5-thioformyluracil toward Nucleophiles and Its Application to Synthesis of Pyrido (2, 3-d) pyrimidines.

K Hirota, K Kubo, H Sajiki

Index: Hirota, Kosaku; Kubo, Keiko; Sajiki, Hironao Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 3 p. 542 - 544

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Citation Number: 4

Abstract

The reaction of the 5-thioformyluracil 1 with phenylhydrazine and various amines readily afforded the hydrazone 3a and Schiff bases 3b-d, respectively. Further, carbanions and Wittig reagents reacted with 1 to give pyrido [2, 3-d] pyrimidines 4 and 9. The corresponding 5-formyluracil 2 possessed much lower reactivities toward these nucleophiles than did 1.