Journal of medicinal chemistry

Antileukemic compounds derived by chemical modification of macrocyclic trichothecenes. 2. Derivatives of roridins A and H and verrucarins A and J

BB Jarvis, JO Midiwo, EP Mazzola

Index: Jarvis, Bruce B.; Midiwo, Jacob O.; Mazzola, Eugene P. Journal of Medicinal Chemistry, 1984 , vol. 27, # 2 p. 239 - 244

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Citation Number: 26

Abstract

Various 8P-hydroxy, 16-hydroxy, and SP, lOP-epoxy derivatives of roridins A and H and verrucarins A and J have been prepared and tested in vivo against P388 mouse leukemia. The SP, lOP-epoxy derivatives and 16-hydroxy derivatives consistently exhibit very high activity. The 8P-hydroxy-9P, lOP-epoxy and 16-hydroxy-9P, lOP-epoxy derivatives of verrucarin A and roridin A exhibit extraordinary activity against P388. The 8P-hydroxy-SP, ...