Thienothiopyran-2-sulfonamides: a novel class of water-soluble carbonic anhydrase inhibitors

…, MB Freedman, CN Habecker, PA Lyle…

Index: Ponticello; Freedman; Habecker; Lyle; Schwam; Varga; Christy; Randall; Baldwin Journal of Medicinal Chemistry, 1987 , vol. 30, # 4 p. 591 - 597

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Citation Number: 107

Abstract

An attempt to develop a water-soluble carbonic anhydrase inhibitor focused on exploring structure-activity relationships in the thienothiopyransulfonamide class. The strategy to influence water solubility while retaining carbonic anhydrase activity involved the introduction of a hydroxyl moiety and adjusting the oxidation state of the sulfur on the thiopyran portion of the molecule. Compounds 4 and 17 best fit the criteria of aqueous ...