Toxicology

Oxidation of alcohols and reduction of aldehydes derived from methyl-and dimethylpyrenes by cDNA-expressed human alcohol dehydrogenases

R Kollock, H Frank, A Seidel, W Meinl, H Glatt

Index: Kollock, Ronny; Frank, Heinz; Seidel, Albrecht; Meinl, Walter; Glatt, Hansruedi Toxicology, 2008 , vol. 245, # 1-2 p. 65 - 75

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Citation Number: 10

Abstract

Some methylated pyrenes can form DNA adducts in rat tissues after benzylic hydroxylation and sulpho conjugation. However, oxidation of the intermediate alcohols to carboxylic acids is an important competing pathway leading to detoxification. We previously showed that co- administration of ethanol or 4-methylpyrazole strongly enhances DNA adduct formation by 1- hydroxymethylpyrene, indicating an involvement of alcohol dehydrogenases (ADHs) in ...