Synthesis and pharmacological properties of soft drug derivatives related to perhexiline

G Marciniak, D Decolin, G Leclerc…

Index: Marciniak; Decolin; Leclerc; Decker; Schwartz Journal of Medicinal Chemistry, 1988 , vol. 31, # 12 p. 2289 - 2296

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Citation Number: 10

Abstract

In the hope of reducing the toxicity of perhexiline, a series of 27 cyclohexylaralkylamines I1 based on the “soft drug” concept and incorporating an amide function were synthesized. In a preliminary screening, compounds were evaluated for their a-adrenolytic activities. Several derivatives, especially N-(cyclohexylphenylmethyl)-2-(cyclohexyl-methy1amino) acetamide (3), N-(cyclohexylphenylmethyl)-2-(homoveratrylmethylamino) acetamide (7), and N-[2-( ...