Tetrahedron

Synthesis of arcyriarubin B and related bisindolylmaleimides

M Brenner, H Rexhausen, B Steffan, W Steglich

Index: Brenner,M.; Rexhausen,H.; Steglich,W. Tetrahedron, 1988 , vol. 44, p. 2887

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Citation Number: 132

Abstract

The reaction of indolyl magnesium bromide with 2, 3-dibromo-N-methylmaleimide (3) in toluene leads to bisindolylmaleimides 6. In THF a monosubstitution product 5 is obtained which after protection of the indole NH-group with the Boc residue can be used to prepare unsymmetrically substituted bisindolylmaleimides, arcyriarubin B given as an example.