Organic letters

Ligand Effects on Negishi Couplings of Alkenyl Halides

A Krasovskiy, BH Lipshutz

Index: Krasovskiy, Arkady; Lipshutz, Bruce H. Organic Letters, 2011 , vol. 13, # 15 p. 3818 - 3821

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Citation Number: 34

Abstract

Negishi couplings at olefinic centers do not always occur with the anticipated maintenance of stereochemistry. The source of erosion has been traced to the ligand, and a modified method has been developed that solves the stereochemical issue and significantly improves yields of Negishi couplings in general.