Tetrahedron

Experiments and speculations on the role of oxidative cyclization chemistry in natural product biosynthesis

CA Townsend, A Basak

Index: Townsend, Craig A.; Basak, Amit Tetrahedron, 1991 , vol. 47, # 14/15 p. 2591 - 2602

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Citation Number: 79

Abstract

Syntheses of [2-2H, 3-13C]-and [2-2H, 3′-2H2] proclavaminic acid,(22) and (29) respectively, are described. These labeled substrates were incubated with clavaminate synthase, a key enzyme acting in the biosynthesis of the lactamase inhibitor clavulanic ...