A series of SAHA cap derivatives was designed and prepared in good-to-excellent yields that varied from 49% to 95%. These derivatives were evaluated for their antiproliferative activity in several human cancer cell lines. Antiproliferative activity was observed for concentrations varying from 0.12 to> 100 μM, and a molecular modeling approach of selected SAHA derivatives, based on available structural information of human HDAC8 in ...
