2??(Het) aryl??Substituted 7??Azabicyclo [2.2. 1] heptane Systems

A Otten, JC Namyslo, M Stoermer…

Index: Otten, Albert; Namyslo, Jan Christoph; Stoermer, Martin; Kaufmann, Dieter E. European Journal of Organic Chemistry, 1998 , # 9 p. 1997 - 2001

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Citation Number: 10

Abstract

Abstract Epibatidine (1) is a recently discovered trace alkaloid found in the skin of a Latin- American poisonous frog. Its remarkably high analgetic activity is accompanied by high toxicity. Therefore, in order to tune its biological activity, a convergent and efficient synthetic pathway was sought to synthesize epibatidine derivatives with different (het) aryl substituents. The hydro (het) arylation of the key intermediate 7-azabicycloheptene (10) ...