Synthesis and evaluation of a radioiodinated benzothiazole derivative as a radioligand for in vivo quantitation of β??amyloid deposits in aging and alzheimer's disease

…, ML Debnath, DP Holt, CA Mathis

Index: Wang, Y.; Klunk, W. E.; Huang, G.-F.; Debnath, M. L.; Holt, D. P.; Mathis, C. A. Journal of Labelled Compounds and Radiopharmaceuticals, 2001 , vol. 44, p. S239 - S241

Full Text: HTML

Citation Number: 9

Abstract

Abstract Amyloid deposits in the form of senile plaques and fibrillary tangles have been targeted as a biomarker for the early diagnosis of Alzheimer's disease (AD) and evaluation of the efficacy of therapeutic treatments (1–3). For in vivo quantitation of amyloid deposits in AD, efforts have been made to develop radiopharmaceuticals for PET and/or SPECT imaging that readily penetrate the blood brain barrier and selectively localize in the area ...