Organic letters

Preparation and Double Michael Addition Reactions of a Synthetic Equivalent of the Nazarov Reagent

M Amat, F Arioli, M Pérez, E Molins, J Bosch

Index: Amat, Mercedes; Arioli, Federica; Perez, Maria; Molins, Elies; Bosch, Joan Organic Letters, 2013 , vol. 15, # 10 p. 2470 - 2473

Full Text: HTML

Citation Number: 6

Abstract

A synthetic equivalent of the Nazarov reagent, the silyl derivative 2, able to undergo base- catalyzed double Michael addition reactions with α, β-unsaturated carbonyl compounds has been developed. The new reagent satisfactorily reacts with unsaturated indolo [2, 3-a] quinolizidine lactams to give pentacyclic yohimbinone-type derivatives.