Journal of the American Chemical Society

Phosphoramidate solvolysis

I Oney, M Caplow

Index: Oeney,I.; Caplow,M. Journal of the American Chemical Society, 1967 , vol. 89, p. 6972 - 6980

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Citation Number: 25

Abstract

Abstract: The solvolytic properties of mono-and dimethyl esters of phosphoramidic acid are reported and compared with previously published data on unsubstituted phosphoramidate. The similarity of the rate constants for the hydrolysis (0.58 hr-l) and solvolysis in 50 2 vjv methanol-water (0.296 hr-I) of neutral monomethyl phosphoramidate at 36.8” to those for neutral phosphoramidic acid suggest a common (bimolecular) mechanism for both ...