Synthesis

Solvent-free synthesis of urea derivatives from primary amines and sulfur under carbon monoxide and oxygen at atmospheric pressure

T Mizuno, M Mihara, T Nakai, T Iwai, T Ito

Index: Mizuno, Takumi; Mihara, Masatoshi; Nakai, Takeo; Iwai, Toshiyuki; Ito, Takatoshi Synthesis, 2007 , # 20 p. 3135 - 3140

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Citation Number: 8

Abstract

Abstract A solvent-free carbonylation and oxidation system aimed at green and sustainable chemistry was developed. With these reactions, an environmentally benign synthesis of urea derivatives could be carried out in good to excellent yields from primary amines and sulfur at ambient pressure of carbon monoxide and oxygen. For example, N, N′-dioctylurea was prepared in 99% yield from two equivalents octylamine and one equivalent sulfur in the ...