Toward an understanding of the chemical etiology for DNA minor??groove recognition by polyamides

MA Marques, RM Doss, AR Urbach…

Index: Marques, Michael A.; Doss, Raymond M.; Urbach, Adam R.; Dervan, Peter B. Helvetica Chimica Acta, 2002 , vol. 85, # 12 p. 4485 - 4517

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Citation Number: 101

Abstract

Abstract Crescent-shaped polyamides composed of aromatic amino acids, ie, 1-methyl-1H- imidazole Im, 1-methyl-1H-pyrrole Py, and 3-hydroxy-1H-pyrrole Hp, bind in the minor groove of DNA as 2: 1 and 1: 1 ligand/DNA complexes. DNA-Sequence specificity can be attributed to shape-selective recognition and the unique corners or pairs of corners presented by each heterocycle (s) to the edges of the base pairs on the floor of the minor ...