Large-Scale Applications of Amide Coupling Reagents for the Synthesis of Pharmaceuticals

JR Dunetz, J Magano…

Index: Ikemoto, Tomomi; Ito, Tatsuya; Hashimoto, Hideo; Kawarasaki, Tadao; Nishiguchi, Atsuko; Mitsudera, Hiroyuki; Wakimasu, Mitsuhiro; Tomimatsu, Kiminori Organic Process Research and Development, 2000 , vol. 4, # 6 p. 520 - 525

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Citation Number: 22

Abstract

... Amide bonds are very frequently incorporated into active pharmaceutical ingredients (API).(2) In fact ... an amine can be implemented under anhydrous conditions using an organic base, such ... Thionyl chloride is the most common reagent in process chemistry for the conversion of ...