Versatile Synthesis of Secondary 2??Amino Thiols and/or Their Disulfides via Thiazolinium Salts

…, JF Lohier, AC Gaumont, J Levillain…

Index: Mercey, Guillaume; Lohier, Jean-Francois; Gaumont, Annie-Claude; Levillain, Jocelyne; Gulea, Mihaela European Journal of Organic Chemistry, 2009 , # 25 p. 4357 - 4364

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Citation Number: 6

Abstract

Abstract Commercially available β-amino alcohols have been transformed into various secondary β-amino thiols and/or their disulfides by using methyl dithioacetate as a source of sulfur. The transformation involves a thiazolinium salt as a versatile key intermediate, which enables easy modulation of the product structure by varying the substituents on the heterocycle and the N-alkylating agent.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 ...