Catalytic enantioselective synthesis of prostaglandin E1 methyl ester using a tandem 1, 4-addition-aldol reaction to a cyclopenten-3, 5-dione monoacetal

…, R Naasz, AJ Minnaard, BL Feringa

Index: Arnold; Naasz; Minnaard; Feringa Journal of the American Chemical Society, 2001 , vol. 123, # 24 p. 5841 - 5842

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Citation Number: 125

Abstract

Conjugate addition reactions are among the most important carbon-carbon bond formation reactions in organic synthesis, 1 and considerable progress has been made in the development of asymmetric Michael additions and 1, 4-additions of organometallic reagents. 2 Recently, highly enantioselective copper-catalyzed conjugate addition reactions of diorganozinc reagents to enones have been reported. 3 Among the various chiral ligands ...