Chemistry and physics of lipids

In vitro lipofection with novel series of symmetric 1, 3-dialkoylamidopropane-based cationic surfactants containing single primary and tertiary amine polar head groups

M Sheikh, J Feig, B Gee, S Li, M Savva

Index: Sheikh, Mohammad; Feig, Jennifer; Gee, Becky; Li, Song; Savva, Michalakis Chemistry and Physics of Lipids, 2003 , vol. 124, # 1 p. 49 - 61

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Citation Number: 16

Abstract

A novel series of symmetric double-chained primary and tertiary 1, 3-dialkoylamido monovalent cationic lipids were synthesized and evaluated for their transfection activities. In the absence of the helper lipid DOPE (1, 2-dioleoyl-sn-glycero-3-phosphoethanolamine), only the primary and tertiary dioleoyl derivatives 1, 3lmp5 and 1, 3lmt5, respectively elicited transfection activity. This is a striking difference between symmetrical 1, 2-diacyl glycerol- ...