Synthesis and structure–antifungal activity Relationships of 3-Aryl-5-alkyl-2, 5-dihydrofuran-2-ones and Their Carbanalogues: further refinement of tentative …

…, V Balšánek, J Kuneš, P Kubanová, V Buchta

Index: Pour, Milan; Spulak, Marcel; Balsanek, Vojtech; Kunes, Jiri; Kubanova, Petra; Buchta, Vladimir Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 13 p. 2843 - 2866

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Citation Number: 62

Abstract

Two series of 3-(substituted phenyl)-5-alkyl-2, 5-dihydrofuran-2-ones related to a natural product,(−) incrustoporine, were synthesized and their in vitro antifungal activity evaluated. The compounds with halogen substituents on the phenyl ring exhibited selective antifungal activity against the filamentous strains of Absidia corymbifera and Aspergillus fumigatus. On the other hand, the influence of the lenghth of the alkyl chain at C (5) was marginal. The ...