Toward a new genetic system with expanded dimensions: size-expanded analogues of deoxyadenosine and thymidine

…, J Gao, L Maynard, YD Saito, ET Kool

Index: Liu, Haibo; Gao, Jianmin; Maynard, Lystranne; Saito, Y. David; Kool, Eric T. Journal of the American Chemical Society, 2004 , vol. 126, # 4 p. 1102 - 1109

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Citation Number: 139

Abstract

We describe the design, preparation, and properties of two key building blocks of a size- expanded genetic system. Nucleoside analogues of the natural nucleosides dA and dT are reported in which the fusion of a benzo ring increases their size by ca. 2.4 Å. The expanded dA analogue (dxA), having a tricyclic base, was first reported by Leonard nearly three decades ago. We describe a shortened and more efficient approach to this compound. ...