Angularly substituted octahydroindoles, decahydroquinolines, octahydropyrindines, and octahydrocyclopenta [b] pyrroles by Bruylants reaction

E Reimann, C Ettmayr, K Polborn

Index: Reimann, Eberhard; Ettmayr, Christian; Polborn, Kurt Monatshefte fur Chemie, 2004 , vol. 135, # 5 p. 557 - 579

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Citation Number: 10

Abstract

Summary. The easily available cycloalkanoyl acetic-and propionic acid esters are transformed to the corresponding amines by standard procedures. These in turn provided an efficient access to cyclic α-aminonitriles, which were reacted with a series of Grignard reagents yielding stereoselectively the cis-configured title compounds; the scope and limitation of this route were investigated. The stereochemical assignment was achieved by ...