Medicinal Chemistry Research

Synthesis and evaluation of fused pyrimidine derivatives as anti-inflammatory, antiproliferative and antimicrobial agents

SD Vachala, KK Srinivasan, PY Prakash

Index: Vachala, Seekarajapuram Dinakaran; Srinivasan, Keloth Kothari; Prakash, Peralam Yegneswaran Medicinal Chemistry Research, 2012 , vol. 21, # 10 p. 2998 - 3005

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Abstract

Abstract In this study, condensation of 2-amino-5-chlorobenzoic acid with benzoyl chloride afforded 2-benzamido-5-chloro benzoic acid which on cyclization with different primary amines yielded the corresponding 6-chloro-2-phenyl-3-substituted quinazolin-4 (3H)-ones (V1–V8). The reaction was monitored by thin layer chromatographic analysis. The structure of the synthesized compounds was confirmed by spectral studies and elemental analysis. ...