Synlett

Annulations Using Phosphonium Salts and Enolate Anions-A Direct Route to Naphthalenes

GA Kraus, PK Choudhury

Index: Kraus, George A.; Choudhury, Prabir K. Synlett, 2004 , # 1 p. 97 - 98

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Citation Number: 3

Abstract

We recently described an annulation reaction of a ketone with aliphatic aldehyde phosphonates. [10] As an extension of that earlier work, we synthesized and evaluated aldehydes 1 and 2 (Scheme [2] ). Both compounds were prepared from the known bromo diester 3 that had been prepared in two steps from o-tolualdehyde. [11] Aldehyde 1 was generated by treatment of 3 with triethylphosphite (70 °C, 24 h) followed by acidic hydrolysis of the geminal ...