Synthesis, hypoglycemic activity and molecular modeling studies of pyrazole-3-carbohydrazides designed by a CoMFA model

E Hernández-Vázquez, R Aguayo-Ortiz…

Index: Hernandez-Vazquez, Eduardo; Aguayo-Ortiz, Rodrigo; Ramirez-Espinosa, Juan Jose; Estrada-Soto, Samuel; Hernandez-Luis, Francisco European Journal of Medicinal Chemistry, 2013 , vol. 69, p. 10 - 21

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Citation Number: 12

Abstract

Abstract Diabetes and obesity are two universal health problems that constitute a research objective of several groups due to the lack of efficient and safe drug treatment. In this sense, cannabinoid receptor 1 (CB1) has attracted interest because of its role in food intake and metabolic balance, two targets in the control of metabolic syndrome. In this work, novel 1, 5- diaryl pyrazole derivatives were synthesized in accordance with the pK i prediction of a ...