e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Synthesis of Homoallylic Chiral Tertiary Alcohols via Chelation-Controlled Diastereoselective Nucleophilic Addition on α-Alkoxyketones: Application for the Synthesis …
PV Ramachandran, H Liu, MV Ram Reddy…
Index: Ramachandran, P. Veeraraghavan; Liu, Haipeng; Reddy, M. Venkat Ram; Brown, Herbert C. Organic Letters, 2003 , vol. 5, # 20 p. 3755 - 3757
Chiral β-syn-alkoxyhomoallylic alcohols derived from alkoxyallylboration of aldehydes upon oxidation provided the corresponding chiral ketones. Chelation-controlled nucleophilic addition to these ketones occurred in a highly stereoselective manner to afford anti- homoallylic tertiary alcohols. This methodology has been applied for the synthesis of the C1- C11 subunit of C8-epi-fostriecin.
