Silicon-mediated synthesis of bibenzyl systems: synthesis of ring and side-chain functionalized hexestrol derivatives

R Mohan, JA Katzenellenbogen

Index: Mohan, Raju; Katzenellenbogen, John A. Journal of Organic Chemistry, 1984 , vol. 49, # 7 p. 1238 - 1246

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Citation Number: 33

Abstract

Derivatives of hexestrol [(3R*, 4S*)-3, 4-bis (4-hydroxyphenyl) hexane], a non-steroidal estrogen, bearing photochemically reactive functional groups or y-emitting radionuclides, are useful as affinity labeling agents for the estrogen receptor or as imaging agents for receptor positive breast tumors, respectively. We have developed convenient synthetic routes to two side chain functionalized and aromatic ring functionalized hexestrol ...