The Discovery of Tadalafil: A Novel and Highly Selective PDE5 Inhibitor. 1: 5, 6, 11, 11a-Tetrahydro-1 H-imidazo [1', 5': 1, 6] pyrido [3, 4-b] indole-1, 3 (2 H)-dione …

A Daugan, P Grondin, C Ruault…

Index: Kumar, Naresh; Dhaon, Madhup K.; Agrawal, Shiv K.; Saxena, Anil K.; Jain, Padam C.; Anand, Nitya Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 12 p. 1087 - 1088

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Citation Number: 135

Abstract

... Journal of Medicinal Chemistry. ... hydantoins 9a−d in good yields. figure Scheme 2 a. a Conditions: (a) Cl−(CH 2 ) 2 −NCO, 2-butanone, reflux; (b) Me 2 NH·HCl, K 2 CO 3 , DMF; (c) R1R2N(CH 2 ) n NH 2 , CDI, THF; (d) THF, reflux. ...