Synthesis and antitumor activity of alkoxynitrobenzyl-bis (2-chloroethyl) amines

…, SS Margaryan, MA Iradyan, BT Garibdzhanyan

Index: Stepanyan, G. M.; Margaryan, S. S.; Iradyan, M. A.; Garibdzhanyan, B. T. Pharmaceutical Chemistry Journal, 1981 , vol. 15, # 2 p. 81 - 84 Khimiko-Farmatsevticheskii Zhurnal, 1981 , vol. 15, # 2 p. 24 - 27

Full Text: HTML

Citation Number: 0

Abstract

The toxicity of the compounds was determined on nonpedigree white mice weighing 18-20 g using a single intraperitoneal injection, and the antitumor activity was studied on rats and mice with transplanted tumors (sarcoma 45, 180, Walker's carcinosarcema, and Erlich's ascites). The absolute lethal dose (LD~ oo), the mean lethal dose (LDso), and the maximum endurable dose (MED) were determined for each compound. A total of 540 mice and 240 ...