Potential antisecretory antidiarrheals. 2.. alpha. 2-Adrenergic 2-[(aryloxy) alkyl] imidazolines

AE Moormann, BS Pitzele, PH Jones…

Index: Moormann, Alan E.; Pitzele, Barnett S.; Jones, P. H.; Gullikson, Gary W.; Albin, David; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 614 - 626

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Citation Number: 22

Abstract

Lofexidine, an aragonist, has central hypotensive activity and peripheral intestinal antisecretory activity. Analogues were synthesized with increased polarity in an attempt to prevent penetration of the blood-brain barrier. The compounds were evaluated in the cholera toxin treated ligated jejunum of the rat and in the Ussing chamber with a rabbit ileum preparation. Active compounds were determined to be a2-adrenergic agonists by ...