Asymmetric Catalysis on the Intramolecular Cyclopropanation of α-Diazo-β-keto Sulfones

…, H Watanabe, A Umino, T Matsumura…

Index: Honma, Masahiro; Sawada, Takashi; Fujisawa, Yuri; Utsugi, Masayuki; Watanabe, Hideaki; Umino, Akinori; Matsumura, Takehiko; Hagihara, Takayuki; Takano, Masashi; Nakada, Masahisa Journal of the American Chemical Society, 2003 , vol. 125, # 10 p. 2860 - 2861

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Citation Number: 106

Abstract

This work describes the development of a highly enantioselective asymmetric catalysis on the intramolecular cyclopropanation of α-diazo-β-keto sulfones. We have found that the catalytic asymmetric intramolecular reactions of α-diazo-β-keto sulfones generally proceed with high enantioselectivity when the α-diazo-β-keto mesityl sulfone is used with the newly prepared ligand 2e. The absolute configuration of products has been determined by X-ray ...